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  • Title: Histopathological Analysis of Brains from Dogs Infected with Canine Distemper Virus.
    Author: Verdes JM, Larrañaga C, Varela B, Iribarnegaray V, Yozzi V, Feijóo G, Yamasaki K.
    Journal: Methods Mol Biol; 2024; 2808():177-195. PubMed ID: 38743371.
    Abstract:
    We describe the use of conventional histology and immunohistochemistry against canine distemper virus (CDV) to examine the brains of domestic dogs with a confirmed diagnosis of CDV infection. Histologically, to identify the main typical lesions, we used conventional H&E stain; to evaluate the progressive demyelination, we used Luxol Fast Blue stain; and to identify the presence of viral particles in these affected regions, we used immunohistochemistry against CDV. We confirm that the histopathological analysis of brains of distemper-infected dogs is a powerful tool to evaluate the typical brain lesions and could be used as an interesting natural model to continue studying the pathogenesis of canine distemper in different species and/or other morbillivirus infections, like measles.
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