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  • Title: Cytotoxic T-cell response to H-Y antigen by B6.C-H-2bm12 and B10.BR mice.
    Author: Juretić A, Juretić E, Nagy ZA, Klein J.
    Journal: Immunology; 1985 Aug; 55(4):671-5. PubMed ID: 3874821.
    Abstract:
    Cytotoxic T-cell response to the male-specific histocompatibility antigen (H-Y) is often used as an experimental model for studying the genetic control of the immune response. This anti-H-Y response is shown to be a complex one, with multicellular interactions involving genes of the H-2 complex, and also some genes unlinked to H-2. For the analysis of the genetic control of the anti-H-Y immune response, different inbred strains have been used and classified accordingly as responders or non-responders. During the authors' studies of the genetic control of the immune response, some of the strains described as non-responders were found to behave as responders, namely strains B6.C-H-2bm12 and B10.BR. This finding has added to the intricacy of current data on the genetic control of immune response to H-Y antigen.
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