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  • Title: [Muramyl dipeptide and its synthetic analog as possible inducers of interleukin-2 production].
    Author: Malaĭtsev VV, Bogdanov IM, Sukhikh GT, Andronova TM.
    Journal: Biull Eksp Biol Med; 1985 Aug; 100(8):221-3. PubMed ID: 3875372.
    Abstract:
    Muramyl dipeptide and its synthetic derivative N-acetyl-glucosaminyl-N-acetyl-muramyl-alanyl - D-isoglutamine induce mitogenic factor production for Con A activated blasts (Con A-blasts) in splenocytes. The maximal factor production was revealed 24 h after stimulation with muramyl dipeptide or its derivative. Addition of the inducers to the culture of Con A-blasts led but to the negligible proliferative response. Therefore, the mitogenic action of muramyl dipeptide on target cells is mediated by the growth factor, evidently by interleukin-2. It has been also shown that muramyl dipeptide and its derivative with Con A exerted a synergic action in interleukin-2 induction.
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