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  • Title: 1-Methyl-4-phenylpyridine (MPP+) is toxic to mesencephalic dopamine neurons in culture.
    Author: Mytilineou C, Cohen G, Heikkila RE.
    Journal: Neurosci Lett; 1985 Jun 04; 57(1):19-24. PubMed ID: 3875812.
    Abstract:
    1-Methyl-4-phenylpyridine (MPP+) is the product of oxidative metabolism by monoamine oxidase of the Parkinson-inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). MPP+ was tested for neurotoxicity on the dopaminergic neurons of embryonic rat midbrain in culture. Compared with MPTP, MPP+ was a more potent neurotoxin for the cultured dopamine (DA) neurons as determined by decrease in [3H]DA uptake by the cultures and decrease in endogenous levels of DA and homovanillic acid. Catecholamine histofluorescence demonstrated the loss of fluorescing fibers after exposure to MPP+. The reduced analogue of MPTP, namely 1-methyl-4-phenylpiperidine, had no significant neurotoxic action on the dopaminergic neurons in culture.
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