These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Studies of vascular permeability factor derived from T lymphocytes and inhibitory effect of plasma on its production in minimal change nephrotic syndrome.
    Author: Tomizawa S, Maruyama K, Nagasawa N, Suzuki S, Kuroume T.
    Journal: Nephron; 1985; 41(2):157-60. PubMed ID: 3876517.
    Abstract:
    Peripheral T lymphocytes from patients with minimal change nephrotic syndrome (MCNS) and controls were treated for their ability to produce vascular permeability factors (VPF) without concanavalin A stimulation. In vitro cultures of T lymphocytes from active MCNS produced VPF in the supernatant, whereas T lymphocytes from inactive MCNS or normal subjects did not. Furthermore, the plasma from patients with active MCNS markedly inhibited VPF production when compared with plasma taken from inactive MCNS or fetal calf serum alone. However, the plasma from MCNS in neither the active nor the inactive stage had any direct blocking effect on VPF activity. These results seem to suggest that the plasma from patients with MCNS in the active stage inhibits VPF production, but does not neutralize T lymphocytes derived VPF activity.
    [Abstract] [Full Text] [Related] [New Search]