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  • Title: Benign and malignant lymphocytic skin infiltrates: immunological patterns recognized by immunohistochemical staining with monoclonal antibodies.
    Author: Ralfkiaer E, Hou-Jensen K, Mason DY, Stein H, Wantzin GL, Thomsen K.
    Journal: Adv Exp Med Biol; 1985; 186():1033-41. PubMed ID: 3876696.
    Abstract:
    Skin biopsies from 150 patients with cutaneous lymphoma, premalignant or "pseudolymphomatous" conditions and benign dermatoses were examined by immunoenzymatic staining of frozen sections with a panel of monoclonal antibodies against lymphocytes, macrophages and accessory cells. Two patterns of infiltration were identified. In one of these T cells associated with Langerhans cells and HLA-DR-positive macrophages of dendritic morphology, were seen. In the other B cell follicles were present in addition to the above type of infiltrate. The latter pattern was restricted to patch tests biopsies, cutaneous lymphocytomas, and malignant lymphomas of B-cell origin. It is concluded that lymphocytic skin infiltrates are divisible into different patterns of immunological reactions similar to those seen in lymphoid organs.
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