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  • Title: Effects of manganese chloride on the outward currents in frog atrial trabeculae.
    Author: Alvarez JL, García M, Dorticós FR, Morlans JA.
    Journal: Can J Physiol Pharmacol; 1985 Sep; 63(9):1065-9. PubMed ID: 3876869.
    Abstract:
    The effects of MnCl2 on outward currents in frog atrial muscle were investigated under voltage-clamp conditions. MnCl2 (3 mmol/L), which completely abolished the slow inward current, produced a decrease in the outward background current (Ib) at potentials positive to -50 mV. The delayed outward current (Ix, time dependent) was not altered by Mn. "Isochronic activation curves" for Ix and decay of current tails at -40 mV remained unaffected after Mn. Effects on Ib probably reflect a decrease in IK1 related to the decrease in Ca influx as well as a reduction in the Na-Ca exchange current.
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