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  • Title: Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP.
    Author: Melamed E, Rosenthal J, Cohen O, Globus M, Uzzan A.
    Journal: Eur J Pharmacol; 1985 Oct 08; 116(1-2):179-81. PubMed ID: 3876943.
    Abstract:
    Combined administration of nomifensine, a DA reuptake inhibitor, and MPTP completely prevented the long-term (30 days post-treatment) striatal DA depletions induced by MPTP in mice. Cotreatment with desipramine and clomipramine or fluoxetine, inhibitors of NE and 5-HT, respectively had no effect on DA neurotoxicity of MPTP. The findings indicate that MPTP (or MPP+) is a substrate for the specific DA reuptake system and may explain, in part, its selective toxic effects on DA neurons.
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