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  • Title: Cerebral blood flow with the continuous infusion of oxygen-15-labeled water.
    Author: Jones SC, Greenberg JH, Dann R, Robinson GD, Kushner M, Alavi A, Reivich M.
    Journal: J Cereb Blood Flow Metab; 1985 Dec; 5(4):566-75. PubMed ID: 3877065.
    Abstract:
    This work describes the determination of CBF in eight normal human subjects with positron emission tomographic (PET) imaging using the continuous intravenous infusion of H2(15)O. A whole-brain CBF model is described that permits the comparison of the CBF values determined using PET with those obtained using other methods. This model includes a correction for whole-brain recovery coefficient, a correction for the underestimation of flow due to the nonlinearity of the CBF model when considering tissue that includes both gray and white matter, the use of in vitro-determined brain-blood partition coefficients for gray and white matter, and a variation of the equilibrium model that permits the arterial concentration to vary. CBF values using this method compare well with values determined previously. Regional determinations using a brain overlay atlas are presented. Radiation dosimetry for the continuous infusion of H2(15)O is also included.
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