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  • Title: Intraocular pressure changes with propofol ('Diprivan'): comparison with thiopentone.
    Author: Mirakhur RK, Shepherd WF.
    Journal: Postgrad Med J; 1985; 61 Suppl 3():41-4. PubMed ID: 3877292.
    Abstract:
    The effects of propofol, a new non-barbiturate intravenous anaesthetic agent, on intraocular pressure (IOP) were assessed and compared with those of thiopentone. IOP was measured using an applanation tonometer for 5 min following administration of induction doses of propofol or thiopentone and inhalation of 66% nitrous oxide in oxygen. Both agents produced a significant fall in IOP for the period of study, by a maximum of 53% with propofol and 40% with thiopentone. Apnoea occurred with similar frequency in the two groups. Use of propofol was associated with a significant fall in arterial pressure and pain on injection in 5 out of 20 patients.
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