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  • Title: [Effect of perioperative antibiotics on septic complications following emergency interventions on the small and large intestine].
    Author: Hancke E, Jaursch JU, Voigt U.
    Journal: Zentralbl Chir; 1985; 110(15):925-31. PubMed ID: 3877384.
    Abstract:
    The effect of perioperative antibiotics on septic complications in emergency bowel surgery was studied by reviewing the charts of patients. The rate of septic complications was essentially reduced in patients, who had received antibiotics pre-, intra- or immediately postoperatively compared with patients without any antibiotic medication (without antibiotics [n = 25] 6 abdominal wound infections, 5 lethal anastomotic disruptions, 2 urinary infections; with antibiotics [n = 24] 0 abdominal wound infections, 2 lethal anastomotic disruptions, 1 urinary and 1 pulmonary infections). Because of the significant reduction of abdominal wound infections which could be achieved in treating patients (X2 = 6,56; p less than 0,05) with antibiotics, these medicaments should be given in emergency bowel surgery with a further prospective controlled study being not necessary.
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