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  • Title: Posterior polymorphous dystrophy of the cornea. An ultrastructural study.
    Author: de Felice GP, Braidotti P, Viale G, Bergamini F, Vinciguerra P.
    Journal: Graefes Arch Clin Exp Ophthalmol; 1985; 223(5):265-71. PubMed ID: 3877658.
    Abstract:
    A corneal button excised from a 2-month-old infant with congenital posterior polymorphous dystrophy of the cornea, a rare disease affecting Descemet's membrane and endothelium, was examined by electron microscopy. We observed irregularly arranged, sometimes multilayered cells with marked epithelial features, lining the posterior surface of the cornea in place of the endothelium, and Descemet's membrane with focal alterations sometimes involving all of its layers. We interpreted these abnormal cells as epithelial-like cells. As these findings were in a very young patient, which is unusual, we concluded that the onset of the disease may take place in the early period of intrauterine life, corresponding to the beginning of Descemet's membrane production.
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