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  • Title: Metal-Free Decarboxylative Allylation of Oxime Esters under Light Irradiation.
    Author: Geniller L, Ben Kraim H, Clot E, Taillefer M, Jaroschik F, Prieto A.
    Journal: Chemistry; 2024 Aug 01; 30(43):e202401494. PubMed ID: 38785147.
    Abstract:
    Allylation reactions, often used as a key step for constructing complex molecules and drug candidates, typically rely on transition-metal (TM) catalysts. Even though TM-free radical allylations have been developed using allyl-stannanes, -sulfides, -silanes or -sulfones, much less procedures have been reported using simple and commercially available allyl halides, that are used for the preparation of the before-mentioned allyl derivatives. Here, we present a straightforward photocatalytic protocol for the decarboxylative allylation of oxime esters using allyl bromide derivatives under metal-free and mild conditions. This methodology yields a diverse variety of functionalized molecules including several pharmaceutically relevant molecules.
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