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  • Title: Rigid congeners of arylpyridazinones. IV. Synthesis and activity of derivatives of the new heterocyclic system 9H-indeno[2,1-c]pyridazine.
    Author: Pinna GA, Curzu MM, Loriga M, Cignarella G, Barlocco D, Malandrino S.
    Journal: Farmaco Sci; 1985 Dec; 40(12):979-86. PubMed ID: 3879224.
    Abstract:
    Representative terms of the new heterocyclic system 9H-indeno[2,1-c]pyridazine have been synthesized. Their antiinflammatory, analgesic and antipyretic activities were evaluated, in order to compare the pharmacological profiles with those of the isomeric series of 5H-indeno[1,2-c]pyridazine previously investigated. The new compounds were, in general, equiactive as analgesic but less active as antiinflammatory and antipyretic agents with respect to their 5H-isomers.
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