These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Qualitative and quantitative Con A binding to mouse lymphocytes, T cell enriched spleen cells and allogeneically stimulated lymphocytes.
    Author: Hückel C, Brock J, Rychly J, Schulz U, Schulze HA.
    Journal: Arch Immunol Ther Exp (Warsz); 1985; 33(5):645-57. PubMed ID: 3879663.
    Abstract:
    The qualitative and quantitative Con A binding behaviour of mouse spleen cells and allogeneically stimulated lymphocytes was investigated by means of fluorescence-optical and cell-electrophoretical methods. Contrary to B lymphocytes and unstimulated cultured T lymphocytes, normal as well as allogeneically stimulated T cells show a decreased electrophoretic mobility after incubation with Con A. This decrease correlates with a higher affinity and specificity to Con A on the one side and with a functional signal of Con A on the other side. Incubation with Con A is a stimulating signal for normal T lymphocytes and a suppressive one for allogeneically stimulated lymphocytes. The 3H-thymidine incorporation of B lymphocytes and unstimulated T cells is not influenced by Con A in spite of Con A binding. The amount of bound molecules is not of decisive importance for the mitogenic cultivated properties of Con A.
    [Abstract] [Full Text] [Related] [New Search]