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  • Title: Alpha 1-antitrypsin-Pittsburgh: a potent inhibitor of human plasma factor XIa, kallikrein, and factor XIIf.
    Author: Scott CF, Carrell RW, Glaser CB, Lewis JH, Colman RW.
    Journal: Trans Assoc Am Physicians; 1985; 98():344-51. PubMed ID: 3879844.
    Abstract:
    AT-P is a potent inhibitor of factor XIa. It has a greater affinity for factor XIa (5.1 X 10(5) M-1 sec-1), than it does for thrombin (3.1 X 10(5) M-1 sec-1). This recently cloned protein may be clinically valuable in the management of disorders involving activation of the contact system of plasma proteolysis.
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