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  • Title: [Neonatal spasms caused by cerebral hemorrhage in alpha 1-anti-trypsin deficiency].
    Author: Radetti G, Pittschieler K, Dordi B, Mengarda G.
    Journal: Helv Paediatr Acta; 1985 Jul; 40(2-3):173-6. PubMed ID: 3879905.
    Abstract:
    This paper describes a case of late neonatal convulsions due to intracranial haemorrhage in a newborn with cholestatic hepatopathy due to PiZZ homozygote alpha-1-antitrypsin deficiency. The deficiency of vitamin K dependent clotting factors, responsible for the haemorrhage, seems to be due to the cholestasis and might have been aggravated by the non-administration of vitamin K at birth and by breast feeding. The response to vitamin K therapy was good.
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