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  • Title: Effect of ascorbate on red blood cell lipid peroxidation.
    Author: Einsele H, Clemens MR, Remmer H.
    Journal: Free Radic Res Commun; 1985; 1(1):63-7. PubMed ID: 3880016.
    Abstract:
    The present study investigates the effect of ascorbate on red cell lipid peroxidation. At a concentration between 0.2 mmol - 20 mmol/1 ascorbic acid reduces hydrogen peroxide-induced red blood cell lipid peroxidation resulting in a marked decrease in ethane and pentane production as well as in haemolysis. Ascorbic acid also shows an antioxidant effect on chelated iron-catalyzed hydrogen peroxide-induced peroxidation of erythrocyte membranes. At a concentration of 10 mmol/1 ascorbic acid totally inhibits oxidative break-down of polyunsaturated fatty acids by radicals originating from hydrogen peroxide. Our results indicate that ascorbate at the chosen concentration has an antioxidant effect on red blood cell lipid peroxidation.
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