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  • Title: High-throughput sequencing of Strongyloides stercoralis - a fatal disseminated infection in a dog.
    Author: Nosková E, Svobodová V, Hypská V, Cerezo-Echevarria A, Kurucová T, Ilík V, Modrý D, Pafčo B.
    Journal: Parasitology; 2024 May; 151(6):587-593. PubMed ID: 38800868.
    Abstract:
    The rhabditid nematode Strongyloides stercoralis is known worldwide as the causative agent of strongyloidiasis in humans. In addition to public health concerns, S. stercoralis also infects dogs, which represent a possible reservoir for potentially zoonotic transmissions. We describe the first confirmed case of fatal disseminated infection in a dog in the Czech Republic. The microscopic and histological results were supported by a complex genotyping approach. Using high-throughput sequencing of the hypervariable region (HVR-IV) of 18S rDNA and Sanger sequencing of the partial cytochrome c oxidase subunit 1 gene (cox1), the potentially zoonotic haplotype/lineage A of S. stercoralis was confirmed, while the solely canine haplotype/lineage B was not found. The development of the disease is mainly associated with immunodeficiency, and in this case, it was triggered by inappropriate treatment, in particular the use of corticosteroids.
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