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  • Title: [Reduction of insulin reserves and exocrine pancreatic secretion in chronic pancreatitis].
    Author: Stock KP, Domschke S, Pichl J, Schneider MU, Domschke W.
    Journal: Dtsch Med Wochenschr; 1985 Jan 25; 110(4):134-6. PubMed ID: 3881238.
    Abstract:
    In 11 persons with normal pancreas function and 21 patients with chronic pancreatitis serum levels of insulin and C-peptide were measured under basal conditions and after maximal stimulation with glucose-tolbutamide-glucagon. Patients with the highest excretory deficiency in the secretin-pancreozymin test had the most marked impairment in endocrine function. In patients with manifest diabetes the exocrine capacity was reduced to an average of 10% of normal. The endocrine parameters correlated linearly with the exocrine ones, most markedly C-peptide reserve with pancreatic enzyme secretion.
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