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  • Title: Lack of growth hormone-dependent somatomedins or growth retardation in hypophysectomized fetal lambs.
    Author: Parkes MJ, Hill DJ.
    Journal: J Endocrinol; 1985 Feb; 104(2):193-9. PubMed ID: 3881555.
    Abstract:
    Fetal lambs were hypophysectomized and, after 8 days of recovery, given infusions of GH, prolactin, thyroxine and insulin with glucose. Hypophysectomy caused no consistent reduction in fetal plasma somatomedin-like activity. Fetal infusions of GH or prolactin caused no consistent change in plasma somatomedin-like activity. It was concluded that fetal somatomedin-like activity is not GH dependent. After hypophysectomy fetal lambs showed no reduction in body weight or length at term.
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