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  • Title: Chronic lymphocytic leukemia in association with a second lymphoproliferative disorder: response to chemotherapy in two cases.
    Author: Gordon LI, Hrushesky W, Oken MM, Kay NE, Rydell RE.
    Journal: Med Pediatr Oncol; 1979; 7(2):111-6. PubMed ID: 388174.
    Abstract:
    The development of either histiocytic lymphoma or Hodgkin disease in association with pre-existing chronic lymphocytic leukemia has been described in the literature as a terminal event. We describe two patients in whom the diagnosis of a second malignant lymphoma was made during life and who achieved objective clinical response after a change in therapy to a more aggressive combination of drugs. We conclude that patients with chronic lymphocytic leukemia who have had a sudden change in their clinical course should have thorough reevaluation, looking specifically for the development of a second lymphoproliferative disorder. If this is discovered, more aggressive therapy should be initiated.
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