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Title: Monoclonal antibody-defined human pancreatic cancer-associated antigens. Author: Schmiegel WH, Kalthoff H, Arndt R, Gieseking J, Greten H, Klöppel G, Kreiker C, Ladak A, Lampe V, Ulrich S. Journal: Cancer Res; 1985 Mar; 45(3):1402-7. PubMed ID: 3882225. Abstract: Three pancreatic cancer-associated antigens were characterized by use of monoclonal antibodies in immunobinding studies with various cellular and soluble target antigens, in immunoprecipitation, and in immunoperoxidase staining. C54-0 represents a tumor-associated Mr 122,000 antigen, which appears to be widely distributed on various epithelial tumors and to a lower extent on normal tissue. C1-N3 antigen exhibited a more restricted distribution, reacting with pancreatic and various gastrointestinal tract tumors as well as with chronically inflamed pancreatic tissue. The most specific antigen expression was observed for C1-P83 antigen, found on all exocrine tumors of the pancreas, but not on normal or chronically inflamed pancreatic tissue.[Abstract] [Full Text] [Related] [New Search]