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  • Title: Effect of haemopoietic stem-cell proliferation regulators on early and late spleen colony-forming cells.
    Author: Wright EG, Lorimore SA, Lord BI.
    Journal: Cell Tissue Kinet; 1985 Mar; 18(2):193-9. PubMed ID: 3882237.
    Abstract:
    An inhibitor and stimulator of CFU-s proliferation can be obtained from haemopoietic tissue containing, respectively, relatively quiescent CFU-s (e.g. normal bone marrow) and proliferating CFU-s (e.g. regenerating bone marrow). Their effects on the proliferative behaviour of steady-state and regenerating marrow CFU-s, which produce colonies 7, 10 and 12 days post-transplantation have been investigated. The results demonstrate changing sensitivities of CFU-s to inhibitor and stimulator as they progress through a developmental age structure, 'Older' CFU-s (producing early spleen colonies) are more sensitive to stimulator, 'Younger' CFU-s (producing late spleen colonies) are more sensitive to inhibitor.
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