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  • Title: Double-blind comparative trials of fluoxetine and doxepin in geriatric patients with major depressive disorder.
    Author: Feighner JP, Cohn JB.
    Journal: J Clin Psychiatry; 1985 Mar; 46(3 Pt 2):20-5. PubMed ID: 3882676.
    Abstract:
    Fluoxetine was compared to doxepin in geriatric out-patients with major depressive illness. At the end of the 6-week double-blind study, the mean endpoint scores for all rating scales were significantly improved over base-line in both treatment groups. A subsequent 48-week open-label study supported the finding that both drugs are efficacious for maintenance therapy in elderly depressed patients. Fluoxetine, which lacks anticholinergic effects and is nonsedating, was well-tolerated by most patients and had fewer total side effects than doxepin. Common drug-related side effects for fluoxetine included nervousness/anxiety and nausea. Common side effects of doxepin were dry mouth, drowsiness/sedation, constipation, and dizziness/lightheadedness.
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