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  • Title: Platelet tropomyosin binding protein is identical with serum albumin.
    Author: Hitchcock-DeGregori SE, Gerhard MD, Brown WE.
    Journal: J Biol Chem; 1985 Mar 10; 260(5):3228-31. PubMed ID: 3882708.
    Abstract:
    We have shown that the platelet tropomyosin binding protein described in the accompanying paper (Gerhard, M. D., DiGirolamo, P. M., and Hitchcock-DeGregori, S. E. (1985) J. Biol. Chem. 260, 3221-3227) is identical with human serum albumin. The immunological determinants are completely shared; the tryptic peptide maps are the same; the proteins comigrate on two-dimensional gels; and the amino acid sequences of the first 33 amino acids are the same. Although human serum albumin in plasma or commercially prepared protein will not bind tropomyosin-Affi-Gel 15, it will bind following purification from plasma by chromatography on hydroxylapatite.
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