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  • Title: A double-blind comparison of clovoxamine and amitriptyline in the treatment of depressed outpatients.
    Author: Gelenberg AJ, Wojcik JD, Newell C, Lamping DL, Spring B.
    Journal: J Clin Psychopharmacol; 1985 Feb; 5(1):30-4. PubMed ID: 3882774.
    Abstract:
    Forty-two outpatients with major depression were treated in a 4-week double-blind parallel-group comparison of the new antidepressant clovoxamine--a member of oximethers of aralkylketones--with amitriptyline. The two drugs were comparable in efficacy, although because of the small sample size a moderate clinical difference between treatments may not have been detected. The magnitude of unwanted effects also was comparable, but clovoxamine produced fewer "anticholinergic" effects; this was determined by patient complaints of typical anticholinergic symptoms, by decreased salivary flow, and by a new signal detection memory test.
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