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  • Title: Efficacy of flecainide in the management of ventricular arrhythmias: comparative study with amiodarone.
    Author: Dubner SJ, Elencwajg BD, Palma S, Mendelzon R, Ramos A, Bertolasi CA.
    Journal: Am Heart J; 1985 Mar; 109(3 Pt 1):523-8. PubMed ID: 3883728.
    Abstract:
    The effects on ventricular arrhythmias of a new class IA drug, flecainide, were compared with those of amiodarone in 10 patients with frequent, chronic, and stable ventricular ectopic beats (VEBs). The study consisted of an initial 1-week, placebo-controlled, baseline period followed by two 12-day, randomized, crossover, double-blind treatment periods with incremental dosage and 1 month of placebo between drug periods. Frequent VEBs, which were present in all 10 patients during both placebo control periods (30 or more VEBs/hour every hour, during 24-hour Holter monitoring), were markedly suppressed (reduction greater than 80%) in nine patients with both drugs (p less than 0.01). There was almost total abolition of the VEBs in six patients with flecainide, and the satisfactory results with a minimal dose in three demonstrate its fast onset of action. Side effects from either agent were infrequent and no discontinuation was necessary. We conclude from our study that flecainide is a highly effective antiarrhythmic agent.
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