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  • Title: Treatment with an ascochlorin derivative, AS-6 increases 45Ca2+ binding on the plasma membrane of adipocytes in db/db mice.
    Author: Hosokawa T, Ando K, Tamura G.
    Journal: Biochem Biophys Res Commun; 1985 Feb 28; 127(1):247-53. PubMed ID: 3884007.
    Abstract:
    Genetically obese diabetic mice (db/db) have greatly diminished 45Ca2+ binding on the plasma membranes of the adipocytes (45-55%) compared with their lean littermates. Treatment for 1 week with a diet admixture of AS-6 (0.1% in the diet) significantly restored the binding to a level comparable to the lean littermates. The addition of AS-6 in vitro had no effect on the binding, which eliminates the possibility that AS-6 is a Ca2+ ionophore. The results suggest that AS-6 treatment enhances the Ca2+ binding by causing structural alteration(s) in the membranes.
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