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  • Title: Qualitative and quantitative determinations of pepsinogen I in gastric cancer and premalignant changes of the stomach.
    Author: Westerveld BD, Pals G, Défize J, Pronk J, Frants RR, Kreuning J, Eriksson AW, Meuwissen SG.
    Journal: Prog Clin Biol Res; 1985; 173():201-12. PubMed ID: 3885251.
    Abstract:
    Previous studies in rats have shown that stomach carcinogens cause a decrease of total pepsinogen content and a decrease of the fastest pepsinogen isozymogen in gastric mucosa before the appearance of carcinoma. In man the presence of Pg 5, and in particular a strong Pg 5, appears to be associated with gastric cancer. Low serum PG I levels were found in patients with gastric cancer, atrophic gastritis, intestinal metaplasia and gastric polyp. In this chapter we review the literature and report our results of PG I isozymogen and serum PG I determinations in 500 patients with various gastric disorders. It is concluded that premalignant changes of the stomach are associated with the presence of a strong Pg 5 isozymogen and with a low serum PG I level.
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