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  • Title: Haemodialysis with prostacyclin (Epoprostenol) alone.
    Author: Rylance PB, Gordge MP, Ireland H, Lane DA, Weston MJ.
    Journal: Proc Eur Dial Transplant Assoc Eur Ren Assoc; 1985; 21():281-6. PubMed ID: 3887374.
    Abstract:
    Dialysis with prostacyclin (Epoprostenol, PGI2) alone prevents platelet activation and endothelial cell stimulation but not the elevation of fibrinopeptide A (FPA), a sensitive marker of fibrin generation. The generation of FPA may explain why some patients develop clot in the dialysis circuit during PGI2-only dialysis. In combination with heparin, PGI2 augments the anticoagulant effect of the heparin as well as providing platelet protection.
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