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  • Title: Mutagenesis by incorporation of alkylated nucleotides.
    Author: Topal MD.
    Journal: Basic Life Sci; 1985; 31():339-51. PubMed ID: 3888179.
    Abstract:
    The cellular DNA precursor pool was shown to be a target for N-methyl-N-nitrosourea, a potent mutagen and carcinogen. O6medGTP, a product of this interaction, was chemically synthesized and shown to be incorporated into DNA in vitro by Klenow E. coli pol I and phage T4 DNA polymerases. O6medGTP incorporated predominantly opposite T template residues and to a lower extent opposite C. At some loci incorporation of O6medGTP caused DNA synthesis arrest. The significance of the behavior of O6medGTP for mutagenesis in vivo is discussed.
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