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  • Title: Radionuclide perfusion scans in the assessment of acute renal transplant rejection.
    Author: Walker RJ, Turner JG, Lynn KL, Swainson CP, Rogers TG, Bailey RR.
    Journal: N Z Med J; 1985 Jun 12; 98(780):428-30. PubMed ID: 3889731.
    Abstract:
    Acute renal transplant rejection is a diagnostic and management problem. In the oliguric patient clinical evaluation and biochemical tests are less helpful than in those with a functioning graft. The perfusion index derived from a 99mTc-diethylenetriamine penta-acetic acid scan may be a more reliable marker of acute rejection. We studied 20 consecutive renal transplant recipients with serial radionuclide imaging to assess the usefulness of the perfusion index. Seventy-two of 74 episodes of acute rejection were evaluated. Thirty-three (46%) episodes were predicted or supported by a change in the perfusion index. In the non-functioning transplant, 12 of 15 (80%) acute rejection episodes were predicted or supported. A scan obtained the day after transplantation confirmed graft artery patency in all patients. The perfusion index is a useful diagnostic test for the diagnosis and management of acute rejection, particularly in the non-functioning transplanted kidney.
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