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  • Title: Aztreonam therapy in experimental meningitis due to Haemophilus influenzae type b and Escherichia coli K1.
    Author: McCracken GH, Sakata Y, Olsen KD.
    Journal: Antimicrob Agents Chemother; 1985 Apr; 27(4):655-6. PubMed ID: 3890733.
    Abstract:
    The penetration of aztreonam into cerebrospinal fluid was 7 to 15% and 9 to 25%, respectively, in experimental Haemophilus influenzae type b and Escherichia coli K1 meningitis. Aztreonam was effective in reducing the number of organisms in cerebrospinal fluid after single-dose and continuous infusion administration, and the median bactericidal titers in cerebrospinal fluid were 1:32 against both meningeal pathogens.
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