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  • Title: [Interaction of the lymph node and splenic lymphocytes of mice in inactivation of allogeneic hematopoietic stem cells].
    Author: Dozmorov IM, Lutsenko GV, Nikolaeva IS, Petrov RV, Rudneva TB.
    Journal: Biull Eksp Biol Med; 1985 May; 99(5):592-4. PubMed ID: 3890981.
    Abstract:
    A study was made of interaction of mouse spleen and lymph node lymphocytes in inactivation of allogeneic stem cells. It was established that T lymphocytes of the lymph nodes and spleen lymphocytes do not interact on combined administration; their action is of additive nature. B lymphocytes of the lymph nodes have a regulating activity both in respect to T lymphocytes of the lymph nodes and lymphocytes of the spleen. The stem cells serve as target. Depending on the stem cells/B lymphocytes ratio B lymphocytes are capable of exerting either helper or suppressor action.
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