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  • Title: Comparison of receptors for cholera and Escherichia coli enterotoxins in human intestine.
    Author: Holmgren J, Lindblad M, Fredman P, Svennerholm L, Myrvold H.
    Journal: Gastroenterology; 1985 Jul; 89(1):27-35. PubMed ID: 3891496.
    Abstract:
    Extraction of lipids from human small intestinal epithelial cells or brush borders removed specific binding sites for cholera toxin completely, but only about 50% of the receptor sites for Escherichia coli heat-labile enterotoxin. Both cholera toxin and E. coli heat-labile enterotoxin bound strongly to ganglioside GM1 in the lipid extract and, to a lesser extent, to another monosialoganglioside and to GD1b. The results suggest that E. coli heat-labile enterotoxin binds to both ganglioside and glycoprotein receptor sites of the human small intestinal epithelium, whereas cholera toxin binding was restricted to the ganglioside receptors.
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