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  • Title: Spiroplasma-like inclusions in Creutzfeldt-Jakob disease.
    Author: Bastian FO.
    Journal: Arch Pathol Lab Med; 1979 Dec; 103(13):665-9. PubMed ID: 389196.
    Abstract:
    Spiral membranous inclusions were discovered on electron microscopic study of brain biopsy tissues from a 46-year-old man with Creutzfeldt-Jakob disease (CJD). These replicate coiled membranous configurations measured 850 to 1,000 nm in length and 75 to 137.5 nm in width and were located within axoplasm, primarily in presynaptic terminals. These inclusions closely resemble Spiroplasma, a plant pathogen, and the finding of these structures in CJD suggests the concurrence of Spiroplasma infection with a human chronic degenerative brain disease.
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