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  • Title: Effect of a polysaccharide fraction from Grifola frondosa on immune response in mice.
    Author: Suzuki I, Itani T, Ohno N, Oikawa S, Sato K, Miyazaki T, Yadomae T.
    Journal: J Pharmacobiodyn; 1985 Mar; 8(3):217-26. PubMed ID: 3891963.
    Abstract:
    The biological and immunomodulating activities of polysaccharide fraction (GF-1), an antitumor poysaccharide fraction from cultured fruiting bodies of Grifola frondosa, was examined in mice. GF-1 showed no cytocidal effect on culturing tumor cells. However, GF-1 induced resistance against Sarcoma 180 in ICR mice which had completely regressed from the tumor by the effect of GF-1. The administration of GF-1 into mice increased the weights or cell numbers of spleen, and peritoneal cavity. GF-1 enhanced the antigen specific antibody response and carbon clearance activity, whereas GF-1 did not show polyclonal B cell activation and mitogenic activities, and the effect on delayed type hypersensitivity.
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