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  • Title: Flunarizine in common migraine: Italian cooperative trial. I. Short-term results and responders' definition.
    Author: Manzoni GC, Bono G, Sacquegna T, Manna V, Lanfranchi M, Micieli G, Cortelli P, Agnoli A.
    Journal: Cephalalgia; 1985 May; 5 Suppl 2():149-53. PubMed ID: 3893735.
    Abstract:
    In order to assess the effects of flunarizine in long-term prophylaxis of common migraine, 120 subjects (90 female and 30 male) were treated with 10 mg at bedtime and followed-up for two years. The effectiveness of the drug was assessed by investigating the variations of the Headache Index (HI) and of the intake of analgesics. The patients considered responders were those with an at least 60% reduction of the HI compared with the baseline value. To assess side effects, on each follow-up examination the patients were weighed and submitted to the Hamilton Rating Scale for Depression, Toulouse-Pieron test for attention, and arousal test. By the third month of therapy, the average monthly HI had decreased from a baseline value of 16.5 +/- 7.0 to 7.5 +/- 4.2. Also by the third month, 60 subjects had proved responders and 50 non-responders; 10 had dropped out of the study because of side effects or for other reasons. The only statistically significant differences between responders and non-responders were in the baseline HI, which was higher among responders, and in the baseline intake of analgesics, which was higher in non-responders.
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