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  • Title: Epoxidation of prostacyclin in the rabbit kidney.
    Author: Wong PY, Malik KU, Taylor BM, Schneider WP, McGiff JC, Sun FF.
    Journal: J Biol Chem; 1985 Aug 05; 260(16):9150-3. PubMed ID: 3894353.
    Abstract:
    In the isolated Tyrode's perfused rabbit kidney, metabolism of [9-3H]prostacyclin was examined. In addition to 7,9-dihydroxy-4,13-diketo-dinor-prostanoic acid, dinor-6-keto-prostaglandin F1 alpha, and pentanorprostaglandin (PG)F1 alpha gamma-lactone, a new, previously unreported, metabolite was isolated and identified by radio-gas chromatography and gas chromatography-mass spectrometry as 5-hydroxy-6-keto-PGF1 alpha. The structure of this metabolite was further confirmed by comparison of the mass spectra to that of the synthetic standard. The formation of 5-hydroxy-6-keto-PGF1 alpha in the kidney suggested epoxidation of prostacyclin via the renal epoxygenase pathway.
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