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  • Title: Decreased binding of insulin to erythrocytes in myotonic dystrophy.
    Author: Sakai K, Takase S, Kumagai K, Shimizu F.
    Journal: Tohoku J Exp Med; 1985 Jun; 146(2):193-9. PubMed ID: 3895577.
    Abstract:
    Recent several studies have shown that the insulin resistance exists in patients with myotonic dystrophy. Using in vitro radioreceptor assay with 125I-labeled insulin, we evaluated the binding of insulin to erythrocytes in patients with myotonic dystrophy. It was found that there was a decreased binding of insulin to erythrocytes in the patients with myotonic dystrophy. On quantitative analysis, this decrease in binding was found to be the result of a decrease in receptor affinity rather than receptor concentration. There was no evidence that the alteration in insulin receptor affinity was due to hyperinsulinemia. All of 7 patients with myotonic dystrophy also were shown to have an excessive response of endogenous insulin to a glucose challenge. No circulating antibody to insulin was found. These data suggest that a decrease in affinity of insulin receptors may, in part, cause insulin resistance and a compensatory elevation of the plasma insulin concentration in patients with myotonic dystrophy.
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