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  • Title: Experimental models of nephrotoxic acute renal failure.
    Author: Stein JH, Fried TA.
    Journal: Transplant Proc; 1985 Aug; 17(4 Suppl 1):72-80. PubMed ID: 3895673.
    Abstract:
    Table 1 summarizes the findings in these three models of nephrotoxic acute renal failure. As can be noted, leakage of filtrate across damaged tubular epithelium is a factor in each instance. Some degree of tubular obstruction is probably present in each model but is of major importance only with severe tubular injury. Hemodynamic alterations and a change in the ultrafiltration coefficient may also play a role in the renal functional impairment. It is not presently possible to quantitatively determine the significance of each of these abnormalities in a given experimental model.
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