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  • Title: Alterations in components of the pineal melatonin synthetic pathway by acute insulin stress in the rat and Syrian hamster.
    Author: Champney TH, Steger RW, Christie DS, Reiter RJ.
    Journal: Brain Res; 1985 Jul 08; 338(1):25-32. PubMed ID: 3896393.
    Abstract:
    Acute insulin stress increased plasma catecholamine levels in both the Syrian hamster and albino rat within 3 h after an intraperitoneal injection of either 5 or 10 units of insulin. In the rat, this stress caused a concurrent increase in pineal serotonin N-acetyltransferase (NAT) activity and melatonin content with no observable change in hydroxyindole-O-methyltransferase (HIOMT) activity. In the hamster, on the other hand, acute insulin stress did not alter pineal NAT activity, but depressed both HIOMT activity and melatonin content up to 3 h after the stress. These results present further evidence that catecholamines do not control hamster pineal melatonin synthesis by the same mechanism as observed in the rat.
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