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  • Title: Unmasking the Silent Threat: Meleney's Synergistic Gangrene in a Healthy Young Woman Without Predisposing Factors.
    Author: Nichkaode P, Haval S.
    Journal: Cureus; 2024 Jul; 16(7):e63849. PubMed ID: 38974393.
    Abstract:
    A rare rapidly-spreading necrotizing infection of the skin and soft tissues, Meleney's synergistic gangrene is characterized by a synergistic infection with both staphylococci and microaerophilic streptococci. This report presents a case of Meleney's synergistic gangrene in a young female patient with no comorbidities and no surgical history who was initially misdiagnosed as a case of perineal abscess and later after the culture report and course of the spread of infection, it was diagnosed as a case of Meleney's synergistic gangrene. The patient underwent serial debridements with a combination of broad-spectrum antibiotic cover followed by secondary closure of the wound and the patient was followed up after three months post-discharge and showed full recovery with no recurrence of infection.
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