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  • Title: The influence of T cells on the initiation and expression of immunological memory.
    Author: Dresser DW, Popham AM.
    Journal: Immunology; 1979 Oct; 38(2):265-74. PubMed ID: 389782.
    Abstract:
    Nude and normal CBA mice have been used in adoptive transfer experiments to analyse the development of immunological memory. The development of B-cell memory to xenogeneic erythrocyte antigens is to a very large degree dependent on the presence of T cells, with IgG memory being somewhat more dependent than IgM memory. In this system, the expression of B memory, that is the transformation of memory cells to antibody-secreting cells under the inductive influence of antigen, is largely dependent on the presence of T cells. Primed (educated) T cells can have an antigen-specific potentiating effect on unprimed B cells in the presence of antigen.
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