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  • Title: Effect of buflomedil on behaviour, memory, and intellectual capacity in patients with dementia. A placebo-controlled study.
    Author: Levinson B, Wright P, Barklem S.
    Journal: S Afr Med J; 1985 Aug 31; 68(5):302-7. PubMed ID: 3898413.
    Abstract:
    A double-blind, placebo-controlled clinical study of the efficacy and safety of buflomedil in the treatment of dementia was conducted in 55 patients. A statistically significant improvement was achieved for such characteristics as mood, self-care, alertness, emotional lability, indifference, hostility, and anxiety. Compared with placebo, buflomedil showed a clear superiority with regard to improvement in cognitive dysfunction and psychosomatic dysfunction, with a trend toward statistical significance in improvement in interpersonal relations. Secondary analysis of a subset of patients without evidence of earlier cerebrovascular accident showed similar clinical responses and statistical findings. Buflomedil was well tolerated.
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