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  • Title: Methylphenidate and children with attention deficit disorder. Dose effects on classroom academic and social behavior.
    Author: Pelham WE, Bender ME, Caddell J, Booth S, Moorer SH.
    Journal: Arch Gen Psychiatry; 1985 Oct; 42(10):948-52. PubMed ID: 3899046.
    Abstract:
    The short-term, dose-response effects of methylphenidate hydrochloride were evaluated on academic and social classroom measures in 29 children with attention deficit disorder. In a double-blind, cross-over design with order randomized, children received a placebo for two weeks and three doses of methylphenidate hydrochloride (0.15 mg/kg, 0.3 mg/kg, and 0.6 mg/kg) for one week each. Dependent measures included the output and accuracy of performance in grade-appropriate reading comprehension workbooks and arithmetic problems, spelling word acquisition, and observations of disruptive and on-task behavior. Beneficial drug effects and linear dose-response curves on all dependent measures were found. The results suggest that beneficial methylphenidate effects on classroom behavior may be accompanied by enhanced academic achievement in some hyperactive children.
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