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  • Title: Early detection of bacteremia pathogens with rapid molecular diagnostic tests and evaluation of effect on intensive care patient management.
    Author: Tatli-Kis T, Yildirim S, Bicmen C, Kirakli C.
    Journal: Diagn Microbiol Infect Dis; 2024 Sep; 110(1):116424. PubMed ID: 38996775.
    Abstract:
    UNLABELLED: İNTRODUCTION: The BioFire FilmArray Blood Culture Identification panel (BCID2), a rapid molecular blood culture identification test based on multiplex nested polymerase chain reaction. The aim of this study was to evaluate clinical outcomes between the period before (pre-BCID2 group) and after (post-BCID2 group) the introduction of the BCID2 panel into our routine practice. METHODS: The primary endpoint was time to optimal antibiotherapy, and the secondary endpoints were duration of hospital and intensive care unit stay, 7-day, 14-day and 28-day mortality rates after bacteremia. RESULTS: The median time from empirical antibiotherapy to optimal antimicrobial therapy was 4560 (IQR;3060-7140) minutes in the pre-BCID2 group and 1715 (IQR;1362- 2776.25) minutes (in the post-BCID2 group (p<0.05). CONCLUSION: Adding the BCID2 panel may improve antibiotic management in critically ill bacteremia patients.
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