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  • Title: [Toxicity of lithium salts in combined use with neuroleptics].
    Author: Sholokhov VM, Petrov VM, Liubimov BI, Samoĭlov NN, Iavorskiĭ AN.
    Journal: Farmakol Toksikol; 1979; 42(4):423-6. PubMed ID: 38997.
    Abstract:
    Experiments on white mice showed that in combined administration of LD16, LD50 or LD84 of aminazin, triphtazine or haloperidol with the same doses of lithium carbonate, chloride or hydroxybutyrate, the lethal dose exceeded the total lethal dose in the event the drugs were administered alone. Non-lethal doses of the lithium salts produced no effect on LD16, LD50 and LD84 of triphtazine and haloperidol, but non-lethal doses of these neuroleptics potentiated the action of lethal doses of the lithium salts. Haloperidol is an exception to the rule since it did not exert such action with respect to lithium chloride. Aminazin and lithium salts increased also each other's toxicity in instances where one of the drugs was administered in a non-lethal dose, whereas the other in a lethal one.
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