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  • Title: Nortriptyline pharmacokinetics and plasma levels: implications for clinical practice.
    Author: Rubin EH, Biggs JT, Preskorn SH.
    Journal: J Clin Psychiatry; 1985 Oct; 46(10):418-24. PubMed ID: 3900052.
    Abstract:
    The pharmacokinetics of TCAs are reviewed with particular emphasis on nortriptyline, the agent most extensively studied. The clinical uses of TCA plasma level-response studies are discussed in relationship to rational dosage adjustment to increase response rates and avoid iatrogenic toxicity. Other important topics discussed include the issue of active metabolites, single-dose prediction studies, and special considerations in treating the elderly and the medically ill.
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